Chicken Alfredo Lasagna

Featured in: Comfort Meals Made Easy

This elegant yet comforting lasagna features tender shredded chicken nestled between sheets of pasta with a luxurious Alfredo sauce and vibrant spinach. Each layer is generously topped with creamy ricotta, mozzarella, and Parmesan for a decadent, restaurant-quality dish. Baked until bubbly and golden, it's perfect for feeding a crowd or creating an impressive weeknight dinner that feels special.

Updated on Sun, 18 Jan 2026 11:35:00 GMT
Golden-brown Chicken Alfredo Lasagna bubbling in a 9x13-inch dish, revealing creamy layers of tender chicken and spinach. Save to Pinterest
Golden-brown Chicken Alfredo Lasagna bubbling in a 9x13-inch dish, revealing creamy layers of tender chicken and spinach. | simplebissara.com

My stovetop was crowded with pots the night I decided to swap red sauce for white in my usual lasagna routine. I had leftover chicken, a jar of Alfredo staring at me from the fridge, and a hunch that cream and mozzarella could turn dinner into something people would actually remember. The kitchen smelled like garlic and melted butter within minutes, and by the time I pulled that bubbling dish from the oven, I knew I'd stumbled onto something worth repeating. It wasn't traditional, but it was exactly the kind of comfort I wanted on a chilly Tuesday.

I made this for my sister's birthday dinner last spring, and she insisted on taking home the leftovers even though I'd already packed her a separate container. Watching her husband scrape the corner of the pan with his fork, trying to get every last bit of cheese, told me everything I needed to know. It's become my go-to when I want to feed a crowd without the stress of timing a dozen side dishes.

Ingredients

  • Cooked chicken breast: Rotisserie chicken is your best friend here, it brings flavor and saves you from poaching or roasting from scratch.
  • Lasagna noodles: Oven-ready noodles are convenient, but I prefer boiling regular ones briefly so they hold their shape and don't turn mushy.
  • Fresh baby spinach: It wilts down to almost nothing, so don't be shy with the amount, and make sure it's well-drained to avoid watery layers.
  • Onion and garlic: Sautéing these first builds a savory base that keeps the Alfredo from tasting one-note or flat.
  • Alfredo sauce: Homemade is luxurious, but a good jarred version works beautifully if you doctor it up with a little extra Parmesan and black pepper.
  • Ricotta cheese: Whole milk ricotta gives you that creamy, slightly fluffy texture, part-skim can turn grainy and dry.
  • Mozzarella and Parmesan: Shred your own if you can, pre-shredded cheese has anti-caking agents that prevent it from melting into that perfect gooey blanket.
  • Egg: This binds the ricotta mixture so it stays put instead of oozing out when you slice.
  • Italian herbs, salt, and pepper: A little dried oregano and basil wakes up the creamy layers without competing with the Alfredo.
  • Fresh parsley: A handful of chopped parsley at the end adds color and a hint of brightness to cut through all that richness.

Instructions

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Prep your oven and dish:
Set your oven to 375°F and grease a 9x13-inch baking dish with a light coating of butter or cooking spray. This prevents sticking and makes cleanup so much easier.
Cook the noodles:
If you're using regular lasagna noodles, boil them until just al dente, then drain and lay them flat on a towel so they don't clump together. Oven-ready noodles can go straight into the layers, but make sure your sauce is generous.
Sauté the aromatics:
Warm a splash of olive oil in a skillet over medium heat, toss in the diced onion, and cook until it turns soft and translucent, about 3 to 4 minutes. Stir in the minced garlic and let it sizzle for just a minute until fragrant.
Wilt the spinach:
Add the chopped spinach to the skillet and stir until it collapses into a dark green tangle, about 2 minutes. Remove from heat and let it cool slightly so the egg in your ricotta mixture doesn't scramble.
Mix the ricotta filling:
In a medium bowl, combine ricotta, egg, half the Parmesan, Italian herbs, salt, and pepper, then fold in the cooled spinach mixture. It should look creamy and flecked with green.
Start layering:
Spread half a cup of Alfredo sauce across the bottom of your baking dish to keep the noodles from sticking. Lay down 4 noodles, spread half the ricotta-spinach mixture over them, scatter half the chicken on top, drizzle with a cup of Alfredo, and sprinkle with about two-thirds of a cup of mozzarella.
Repeat the layers:
Add another layer of 4 noodles, the remaining ricotta-spinach, the rest of the chicken, another cup of Alfredo, and another two-thirds cup of mozzarella. Keep the layers even so every slice has a balanced bite.
Finish with noodles and cheese:
Top with the final 4 noodles, pour the remaining Alfredo sauce over them, and cover with the rest of the mozzarella and Parmesan. The cheese should blanket the entire surface.
Cover and bake:
Tent the dish with foil and slide it into the oven for 30 minutes. The foil traps steam and helps everything cook through without drying out.
Uncover and finish:
Remove the foil and bake for another 20 to 25 minutes until the top is golden and bubbling at the edges. The cheese should have browned spots and smell irresistible.
Rest before slicing:
Let the lasagna sit for 10 to 15 minutes before cutting into it. This resting time lets the layers set so your slices hold together instead of sliding apart.
Garnish and serve:
Sprinkle fresh chopped parsley over the top for a pop of color and a hint of freshness. Serve with a simple green salad and maybe some crusty bread to soak up the sauce.
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Freshly baked Chicken Alfredo Lasagna slice on a white plate, garnished with parsley and ready to serve. Save to Pinterest
Freshly baked Chicken Alfredo Lasagna slice on a white plate, garnished with parsley and ready to serve. | simplebissara.com

The first time I reheated a square of this for lunch the next day, I was shocked that it tasted even better than the night before. The flavors had mingled overnight, the pasta had soaked up every bit of sauce, and the edges were just crispy enough to make me fight my husband for the corner piece. It's the kind of dish that makes leftovers feel like a reward instead of a chore.

Swaps and Substitutions

You can easily swap kale for spinach if that's what you have on hand, just chop it finely and give it an extra minute in the pan to soften. Gluten-free noodles work beautifully as long as you don't overcook them, they tend to get mushy faster than regular pasta. If you want to skip the chicken, try adding cooked Italian sausage or even roasted mushrooms for a vegetarian twist that still feels hearty. A pinch of nutmeg in the ricotta mixture adds a subtle warmth that plays nicely with the cream, and swapping half the mozzarella for fontina gives you a richer, slightly nutty flavor.

Make-Ahead Magic

This lasagna is a dream for anyone who likes to get dinner started before the day gets away from them. You can assemble the whole thing up to 24 hours ahead, cover it tightly with plastic wrap and foil, and keep it in the fridge until you're ready to bake. Just add an extra 10 minutes to the covered baking time since it will go into the oven cold. I've also frozen unbaked lasagna for up to two months, thaw it overnight in the fridge before baking, and it comes out just as creamy and cheesy as if you'd made it fresh.

Serving Suggestions and Pairings

This dish is rich enough to be the star of the table, so keep your sides simple and bright to balance all that cream. A crisp arugula salad with lemon vinaigrette cuts through the richness, and roasted asparagus or green beans add a little crunch and color. Garlic bread is a given, but I also love serving it with a light Italian white wine like Pinot Grigio or a sparkling water with lemon to cleanse the palate between bites.

  • Pair it with a Caesar salad for a classic steakhouse vibe that everyone loves.
  • Serve garlic knots on the side so guests can mop up every last bit of Alfredo from their plates.
  • A chilled glass of Chardonnay or even a light red like Pinot Noir complements the creamy sauce without overpowering it.
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Steaming Chicken Alfredo Lasagna casserole straight from the oven, featuring golden mozzarella and rich Alfredo sauce. Save to Pinterest
Steaming Chicken Alfredo Lasagna casserole straight from the oven, featuring golden mozzarella and rich Alfredo sauce. | simplebissara.com

There's something deeply satisfying about pulling a pan of this out of the oven and watching everyone's eyes light up at the table. It's comfort food that feels special enough for company but easy enough to make on a weeknight when you just want something warm and filling.

Recipe FAQs

Can I prepare this lasagna ahead of time?

Yes, assemble the lasagna completely, cover tightly with plastic wrap, and refrigerate for up to 24 hours before baking. Add 10-15 minutes to baking time if cooking from cold. You can also freeze assembled lasagna for up to 3 months; thaw overnight in the refrigerator before baking.

What's the best way to prevent a watery lasagna?

Ensure your Alfredo sauce is thick enough and not diluted. If using fresh spinach, squeeze out excess moisture after cooking. Don't skip the cooling step for the spinach mixture before layering, as this prevents water from seeping into the pasta.

Can I use store-bought Alfredo sauce instead of homemade?

Absolutely. Store-bought Alfredo sauce is convenient and works well. Choose a high-quality brand, and if it seems too thin, simmer it gently for a few minutes to reduce and concentrate the flavor before using.

What vegetables can I add to enhance this dish?

Consider adding sun-dried tomatoes, roasted mushrooms, or zucchini. Layer them between other ingredients, ensuring they're not too wet. Peas or corn can also be mixed into the ricotta layer for added texture and nutrition.

How do I know when the lasagna is properly baked?

The lasagna should be bubbly around the edges and the top should be golden brown. Insert a knife into the center; it should go through easily without meeting heavy resistance. Let it rest 10-15 minutes before serving to set the layers.

Can I substitute the ricotta cheese with something else?

You can use mascarpone for a richer flavor, or combine cottage cheese with cream cheese for a similar texture. Avoid using only mozzarella, as ricotta's mild taste and creamy texture are essential to the dish's character.

Chicken Alfredo Lasagna

Layered pasta dish combining shredded chicken, creamy Alfredo sauce, spinach, and melted cheeses for an indulgent Italian-American comfort meal.

Prep Time
30 minutes
Cook Time
55 minutes
Overall Time
85 minutes
Recipe by Ava Turner


Skill Level Medium

Cuisine Type Italian-American

Portions 8 Number of Servings

Dietary Info None specified

What You'll Need

Proteins

01 3 cups cooked chicken breast, shredded or diced

Pasta

01 12 lasagna noodles, regular or oven-ready

Vegetables

01 2 cups fresh baby spinach, roughly chopped
02 1 medium onion, finely diced
03 3 cloves garlic, minced

Sauces and Dairy

01 4 cups Alfredo sauce, store-bought or homemade
02 2 cups whole milk ricotta cheese
03 2 cups shredded mozzarella cheese
04 1 cup grated Parmesan cheese
05 1 large egg

Spices and Seasonings

01 1 teaspoon dried Italian herbs
02 1/2 teaspoon salt
03 1/4 teaspoon black pepper
04 2 tablespoons fresh parsley, chopped for garnish

How to Make It

Direction 01

Preheat oven and prepare baking dish: Preheat oven to 375°F. Lightly grease a 9x13 inch baking dish.

Direction 02

Cook lasagna noodles: If using regular lasagna noodles, cook according to package instructions until al dente. Drain and set aside.

Direction 03

Sauté aromatics: In a skillet over medium heat, sauté diced onion in olive oil for 3-4 minutes until softened. Add minced garlic and cook for 1 minute more.

Direction 04

Wilt spinach: Stir in chopped spinach and cook until wilted, approximately 2 minutes. Remove from heat and allow to cool slightly.

Direction 05

Prepare ricotta mixture: In a medium bowl, combine ricotta cheese, egg, half of the Parmesan cheese, Italian herbs, salt, and pepper. Mix in the cooled spinach mixture until well incorporated.

Direction 06

Build first layer: Spread 1/2 cup Alfredo sauce on the bottom of the prepared baking dish. Layer 4 noodles over the sauce.

Direction 07

Assemble middle layers: Spread half of the ricotta-spinach mixture over noodles. Scatter half the chicken on top. Drizzle with 1 cup Alfredo sauce and sprinkle with 2/3 cup mozzarella. Repeat with another layer of noodles, remaining ricotta-spinach, remaining chicken, 1 cup Alfredo sauce, and 2/3 cup mozzarella.

Direction 08

Complete top layer: Top with final layer of noodles, remaining Alfredo sauce, remaining mozzarella, and remaining Parmesan cheese.

Direction 09

Bake covered: Cover with foil and bake for 30 minutes.

Direction 10

Finish baking: Remove foil and bake an additional 20-25 minutes until bubbly and golden brown.

Direction 11

Rest and garnish: Let stand for 10-15 minutes before slicing. Garnish with fresh parsley if desired.

Tools Needed

  • 9x13 inch baking dish
  • Large skillet
  • Medium mixing bowl
  • Saucepan for Alfredo sauce preparation
  • Measuring cups and spoons
  • Aluminum foil

Allergy Details

Always review all ingredients for allergens and check with a healthcare provider if uncertain.
  • Contains wheat from pasta
  • Contains milk and milk products
  • Contains egg
  • May contain tree nuts if using nut-based Alfredo sauce

Nutrition Details (per serving)

Nutritional data is just for reference. Please don't treat it as medical or dietary advice.
  • Calories Count: 510
  • Fats: 27 g
  • Carbohydrates: 33 g
  • Proteins: 34 g